期刊
JOURNAL OF PROTEOME RESEARCH
卷 7, 期 6, 页码 2222-2233出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr700841q
关键词
AFP-L3; core-fucosylation; glycosyltransferase; hepatocellular carcinoma; LCA-affinity electrophoresis; N-glycan; tumor marker
The N-glycan structures of the Lens culinaris agglutinin (LCA)-reactive fraction of alpha-fetoprotein (AFP-L3), a tumor marker of hepatocellular carcinomas (HCC), were analyzed in relationship to glycosyltransferases and LCA-affinity electrophoresis. Using HPLC and MALDI-TOF MS, we determined the N-glycan structures of AFP from HCC cell lines, and demonstrated they were affected by N-acetylglucosaminyltransferase III and fucosyltransferase VIII, but not by N-acetylglucosaminyltransferase V. Moreover, we identified the N-glycan structures of AFP in HCC patients.
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