期刊
JOURNAL OF PROTEOME RESEARCH
卷 7, 期 12, 页码 5295-5313出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr800540h
关键词
Phosphoinositides; proteomics; interactome; microaffinity purification
A comprehensive analysis of the phosphoinositide interactome has been performed using analogues of PI(3,5)P2 and PI(4,5)P2 phosphatidyl phospholipids which were immobilized onto Affi-10 beads or incorporated into liposomes for use as affinity absorbents with cytosolic extracts from colonic carcinoma cell lines. Affinity/LC/MS/MS experiments allowed identification of 388 proteins/protein complexes that appeared to interact specifically with the phosphoinositide targets: a number of novel potential phosphoinositide interacting proteins have been identified.
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