期刊
PHYSIOLOGY
卷 30, 期 5, 页码 340-348出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00022.2015
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- National Heart, Lung, and Blood Institute [PO1-HL-90554, UH2-HL-123610]
The discovery of carotid bodies as sensory receptors for detecting arterial blood oxygen levels, and the identification and elucidation of the roles of hypoxia-inducible factors (HIFs) in oxygen homeostasis have propelled the field of oxygen biology. This review highlights the gas-messenger signaling mechanisms associated with oxygen sensing, as well as transcriptional and non-transcriptional mechanisms underlying the maintenance of oxygen homeostasis by HIFs and their relevance to physiology and pathology.
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