期刊
PHYSIOLOGICAL MEASUREMENT
卷 36, 期 3, 页码 441-452出版社
IOP PUBLISHING LTD
DOI: 10.1088/0967-3334/36/3/441
关键词
heart rate variability; time-frequency analysis; time-varying autoregressive model; electrocardiogram; cold pressor test
资金
- National Basic Research Program 973 [2010CB732606]
- Guangdong Innovation Research Team Fund for Low-cost Healthcare Technologies in China
- External Cooperation Program of Chinese Academy of Sciences [GJHZ1212]
- Key Lab for Health Informatics of Chinese Academy of Sciences
- Peacock Program to Attract Overseas High-Caliber Talents to Shenzhen
- National Natural Science Foundation of China [61401453]
- Shenzhen Municipal Government [KFJ-EW-STS-097, KFJ-EWSTS-095]
Heart rate variability is a useful clinical tool for autonomic function assessment and cardiovascular disease diagnosis. To investigate the dynamic changes of sympathetic and parasympathetic activities during the cold pressor test, we used a time-varying autoregressive model for the time-frequency analysis of heart rate variability in 101 healthy subjects. We found that there were two sympathetic peaks (or two parasympathetic valleys) when the abrupt changes of temperature (ACT) occurred at the beginning and the end of the cold stimulus and that the sympathetic and parasympathetic activities returned to normal in about the last 2 min of the cold stimulus. These findings suggested that the ACT rather than the low temperature was the major cause of the sympathetic excitation and parasympathetic withdrawal. We also found that the onsets of the sympathetic peaks were 4-26 s prior to the ACT and the returns to normal were 54-57 s after the ACT, which could be interpreted as the feedforward and adaptation of the autonomic regulation process in the human body, respectively. These results might be helpful for understanding the regulatory mechanisms of the autonomic system and its effects on the cardiovascular system.
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