期刊
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
卷 15, 期 9-10, 页码 918-929出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S108842461100380X
关键词
intracellular localization; metalloisoporphyrins; porphyrins; synthesis; toxicity
资金
- US National Institutes of Health [CA 132861, CA 139385]
b-Bilene hydrochlorides are shown to be improved intermediates for the synthesis of metallo-isoporphyrins in enhanced yields (28% vs. 6%). Several new diamagnetic zinc(II) and a novel paramagnetic copper(II) isoporphyrin salts were also obtained using this approach. Metal-free isoporphyrins were also isolated. In vitro studies using human carcinoma HEp2 cells show that all metallo-isoporphyrins accumulate within cells and localize partially in the mitochondria. The zinc-isoporphyrins were found to be moderately phototoxic while the copper complex showed the lowest phototoxicity, maybe as a result of its paramagnetic nature.
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