期刊
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
卷 13, 期 4-5, 页码 567-573出版社
WORLD SCI PUBL CO INC
DOI: 10.1142/S1088424609000553
关键词
bacteriochlorins; porphyrins; synthesis; photophysics; photodynamic therapy; PDT
资金
- Camara Municipal de Coimbra
- Comissao de Coordenacao e Desenvolvimento Regional do Centro
- Bluepharma SA
- Programa Operacional da Regiao Centro
- Medida 1.5 Feder
- FCT [PTDC/QUI/66015/2006, SFRH/BD/37652/2007]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/37652/2007, PTDC/QUI/66015/2006] Funding Source: FCT
Photodynamic therapy (PDT) is a promising treatment for several types of cancers. It involves the synergetic effect of light, oxygen and an appropriate photosensitizer. Extensive studies on the synthetic modulation of the structure of tetrapyrrolic macrocycles allowed for the optimization of chemical and physical properties of such photosensitizers. The progress from porphyrins to chlorins and more recently to bacteriochlorins clearly shows the improvements achieved in PDT photosensitizers. This paper summarizes our recent contribution to the synthesis of stable amphiphilic halogenated meso-tetraarylbacteriochlorins. Their photophysics, in vitro cytotoxicity and phototoxicity are presented and their potential use as photosensitizer for PDT application is assessed.
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