期刊
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
卷 13, 期 1, 页码 51-59出版社
WORLD SCI PUBL CO INC
DOI: 10.1142/S1088424609000085
关键词
porphyrin; carbohydrate; PDT; click chemistry
资金
- US National Institutes of Health [CA098902]
Using a Cu(I)-catalyzed carbohydrate azide-alkynylphenylporphyrin cycloaddition (the so-called click chemistry), we have synthesized in high yields, a series of four new porphyrin-carbohydrate conjugates containing either one or four galactose or lactose moieties linked via triazole units to a meso-phenyl group of a TPP or tetrabenzoporphyrin (TBP) macrocycle. The time-dependent uptake and subcellular distribution of this series of porphyrin-carbohydrate conjugates were evaluated in human carcinoma HEp2 cells. While the three TPP conjugates accumulated to a similar extent within cells and localized mainly in the ER and endosomes, the TBP-galactose conjugate was the one most efficiently taken up by the HEp2 cells, accumulating approximately 5 times more than the TPP Conjugates, and localized preferentially within the cell lysosomes.
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