期刊
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
卷 51, 期 9, 页码 742-748出版社
WILEY-BLACKWELL
DOI: 10.1002/polb.23249
关键词
B. mori silk fibroin; biomineralization; biopolymers; hydroxyapatite crystals; interfaces; nucleation; self-assembly
资金
- National Natural Science Foundation of China [20804037, 21172194]
- Zhejiang Provincial Natural Science Foundation of China [LZ12C17001]
- Fundament Research Funds for the Center Universities [2009QNA6037]
Bombyx mori silk fibroin (SF) is known to be capable of facilitating nucleation of the hydroxyapatite crystals (HAps). To find out how SF mediates the nucleation of HAps, self-assembly of SF in 1.5 simulated body fluid (SBF) was observed in this study through design of a co-solution of SF and 1.5-times SBF (SF/1.5 SBF). After the co-solution of SF/1.5 SBF was incubated at 37.2 degrees C up to 7 days, SEM, X-ray, and Fourier transform infrared (FTIR) observations indicated that nucleation of HAps was increased. In addition, the structure of SF was transited from random coil into -sheet indicated by FTIR spectra. The -sheet assembly of SF in 1.5 SBF was also supported by CD spectra. Atomic force microscopy provided detailed progress of the self-assembly that SF incubated in 1.5 SBF was self-assembled in the form from dot, through rod to final net. Therefore, this study suggested that nucleation of HAps of SF was controlled by its molecular self-assembly. (c) 2013 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2013, 51, 742-748
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