期刊
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
卷 52, 期 2, 页码 287-294出版社
WILEY
DOI: 10.1002/pola.27002
关键词
biodegradable polymers; biocompatible polymers; polymer therapeutics; polyphosphazenes; water-soluble polymers
资金
- Austrian Science Fund (FWF) [P24659-N28]
- Johannes Kepler University Linz
- Basque Government's Global Training Grant Programme
- European Union [M00146]
- Austrian Science Fund (FWF) [P24659] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 24659] Funding Source: researchfish
The synthesis of a series of novel, water-soluble poly(organophosphazenes) prepared via living cationic polymerization is presented. The degradation profiles of the polyphosphazenes prepared are analyzed by GPC, P-31 NMR spectroscopy, and UV-Vis spectroscopy in aqueous media and show tunable degradation rates ranging from days to months, adjusted by subtle changes to the chemical structure of the polyphosphazene. Furthermore, it is observed that these polymers demonstrate a pH-promoted hydrolytic degradation behavior, with a remarkably faster rate of degradation at lower pH values. These degradable, water soluble polymers with controlled molecular weights and structures could be of significant interest for use in aqueous biomedical applications, such as polymer therapeutics, in which biological clearance is a requirement and in this context cell viability tests are described which show the non-toxic nature of the polymers as well as their degradation intermediates and products. (c) 2013 The Authors Journal of Polymer Science Part A: Polymer Chemistry Published by Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 287-294
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