期刊
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
卷 51, 期 1, 页码 59-70出版社
WILEY
DOI: 10.1002/pola.26387
关键词
APTES; functionalization of polymers; micromixer; mixing; thermoplastics
资金
- Ministere de L'enseignement Superieur et de la Recherche (MESR)
- SensorART project
- European Communities Seventh Framework Programme [248763]
- Spanish Government through the MINAHE 3 project [MEC-TEC2008-06883-CO3-01]
Over the past few years, a growing interest on covalent bonding of polydimethylsiloxane (PDMS) microfluidic devices to thermoplastic films has developed due to reduced costs, biocompatibility, and flexibility. The silane reagent, 3-aminopropyltriethoxysilane (APTES) has been applied to create this bonding. Here, we report on the fabrication of replica PDMS micromixer devices from a silicon mold using soft lithography that is rapid, facile, and cost-effective to manufacture. After replica molding, the PDMS micromixer devices were bonded to the APTES-activated thermoplastic films of polyimide, polyethylene terephthalate, and polyethylene naphthalate. Characterization of these thermoplastic surfaces was analyzed by contact angle measurement, surface free energy, and X-ray photoelectron spectroscopy. To demonstrate the functionality of this technology, we have analyzed the PDMS micromixers by a peel test, nonleakages, and mixing with the injection of inks, a surfactant, and varying pH solutions. To our knowledge, this is the first reported example in literature of the PDMSAPTESthermoplastic films preparation that integrates a complex micromixer device. Here, we have established that the hydrophobicity of both sealed polymers required alteration in order for dispersion of a polar liquid in the mixing loops. The application of a polar solvent before injection can remedy this ill effect formulating a hydrophilic micromixer. These preliminary results demonstrate the feasibility of the fabrication technology, bonding technique, and application of the micromixer that, once optimized, can eventually integrate more components to formulate a lab-on-a-chip with the fabrication of gold microelectrodes for biological analysis of blood or plasma. (C) 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据