期刊
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
卷 48, 期 14, 页码 3178-3187出版社
WILEY
DOI: 10.1002/pola.24105
关键词
atom transfer radical polymerization (ATRP); bio-polymers; carbohydrate ligand; click chemistry; functionalization of polymers; nanoparticles; ring-opening polymerization
The aim of this work was to prepare nanoparticles bearing sugar residues at their surface through the synthesis of amphiphilic block copolymer of poly d,l-lactide (PLA) and poly(ethylene glycol)methacrylate, with the hydrophilic part terminating with glucopyranoside molecules as a model for any carbohydrate ligand. The construction was achieved by a combination of click chemistry, ring-opening polymerization, and atom transfer radical polymerization. The modified monomer and resulting copolymer were characterized by NMR, SEC, and FTIR. Nanoparticles with a mean hydrodynamic diameter of <200 nm as determined by quasi-elastic light scattering were prepared from the amphiphilic copolymer by nanoprecipitation using dimethylforrnamide (DMF) as water-miscible solvent. In the range of 2.5-10 mg copolymer/mL DMF, the polymer concentration did not have much effect on the size of the nanoparticles. Accessibility of glucopyranoside molecules on the surface of the nanoparticles was confirmed by formation of aggregates from nanoparticles in the presence of concanavalin A observed by transmission electronic microscopy. Finally, no significant cytotoxicity toward human umbilical vein endothelial cells was detected for the final nanoparticles. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 3178-3187, 2010
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据