期刊
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
卷 47, 期 23, 页码 6388-6395出版社
WILEY
DOI: 10.1002/pola.23679
关键词
adenine; biomaterials blending biopolymers; self-assemble; supramolecular complexes; supramolecular structures; thymine; uracil
资金
- Ministry of Education's Aim for the Top University (MOEATU) program
- National Science Council, Taiwan [NSC-96-2120-M-009-009]
A series of nucleobased polymers and copolymers were synthesized through atom transfer radical polymerization (ATRP). Biocomplementary DNA-and RNA-like supramolecular complexes are formed in dilute DMSO solution through nucleobase recognition. H-1 NMR titration studies of these complexes in CDCl3 indicated that thymine-adenine (T-A) and uracil-adenine (U-A) complexes form rapidly on the NMR time scale with high association constants (up to 534 and 671 M-1, respectively) and result in significant T-g increase. WAXD and differential scanning calorimetry analyzes in the bulk state indicate the presence of highly physical crosslinked structures and provide further details into the nature of the self-assembly of these systems. Furthermore, this study is of discussion on the difference in the hydrogen bond strength between T-A and U-A base pairs within polymer systems, indicating that the strength of hydrogen bonds in RNA U-A pairs is stronger than that in DNA T-A base pairs. (C) 2009 Wiley Periodicals, Inc. J Polym. Sci Part A: Polym Chem 47:6388-6395, 2009
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