期刊
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
卷 47, 期 16, 页码 4001-4013出版社
WILEY
DOI: 10.1002/pola.23461
关键词
atom transfer radical polymerization (ATRP); block copolymers; supramolecular structures
资金
- National Natural Scientific Foundation of China (NNSFC) Projects [20534020, 20674079, 20874092, 50425310]
- Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP)
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)
Well-defined amphiphilic and thermoresponsive ABC miktoarm star terpolymer consisting of poly(ethylene glycol), poly(tert-butyl methacrylate), and poly(N-isopropylacrylamide) arms, PEG(-b-PtBMA)-b-PNIPAM, was synthesized via a combination of consecutive click reactions and atom transfer radical polymerization (ATRP). Click reaction of monoalkynyl-terminated PEG with a trifunctional core molecule bis(2-azidoethyl)amine, (N-3)(2)-NH, afforded difunctional PEG possessing all azido and a secondary amine moiety at the chain end, PEG-NH-N-3. Next, the amidation of PEG-NH-N-3 with 2-chloropropionyl chloride led to PEG-based ATRP macroinitiator, PEG(-N-3)-Cl. The subsequent ATRP of N-isopropylacrylamide (NIPAM) using PEG(-N-3)-Cl as the macroinitiator led to PEG(-N-3)-b-PNIPAM bearing an azido moiety at the diblock junction point. Finally, well-defined ABC miktoarm star terpolymer, PEG(-b-PtBMA)-b-PNIPAM, was prepared via the click reaction of PEG(-N-3)-b-PNIPAM with monoalkynyl-terminated PtBMA. In aqueous solution, the obtained ABC miktoarml star terpolymer self-assembles into micelles consisting of PtBMA cores and hybrid PEG/PNIPAM coronas, which are characterized by dynamic and static laser light scattering, and transmission electron microscopy. On heating above the phase transition temperature of PNIPAM in the hybrid corona, micelles initially formed at lower temperatures undergo further structural rearrangement and fuse into much larger aggregates solely stabilized by PEG coronas. (C) 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 4001-4013, 2009
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