期刊
JOURNAL OF POLYMER RESEARCH
卷 18, 期 4, 页码 739-744出版社
SPRINGER
DOI: 10.1007/s10965-010-9470-9
关键词
Bacterial cellulose; Chitosan; Scaffold; Mechanical properties; Cell adhesion
资金
- Creative Research Initiatives (EAPap Actuator) of NRF/MEST
Bacterial cellulose (BC)/Chitosan (Ch) composite has been successfully prepared by immersing wet BC pellicle in Ch solution followed by freeze-drying process. The morphology of BC/Ch composite was examined by scanning electron microscope (SEM) and compared with pristine BC. SEM images show that Ch molecules can penetrate into BC forming three-dimensional multilayered scaffold. The scaffold has very well interconnected porous network structure and large aspect surface. The composite was also characterized by Fourier transform infrared spectrum, X-ray diffraction, thermogravimetric analysis and tensile test. By incorporation of Ch into BC, crystallinity tends to decrease from 82% to 61%, and the thermal stability increases from 263 A degrees C to 296 A degrees C. At the same time, the mechanical properties of BC/Ch composite are maintained at certain levels between BC and Ch. The biocompatibility of composite was preliminarily evaluated by cell adhesion studies. The cells incubated with BC/Ch scaffolds for 48 h were capable of forming cell adhesion and proliferation. It showed much better biocompatibility than pure BC. Since the prepared BC/Ch scaffolds are bioactive and suitable for cell adhesion, these scaffolds can be used for wound dressing or tissue-engineering scaffolds.
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