Monoacrylated cyclodextrin via click reaction and copolymerization with N-isopropylacrylamide: guest controlled solution properties

Mono-(1 H-1, 2, 3-triazol-4-yl) (methyl) 2-methylacryl- beta-cyclodextrin (CD) 3 is synthesized by microwave assisted 'click' reaction of propargyl (meth) acrylate and mono-(6-azido-6-deoxy)-beta-CD using Cu (I) catalysis. Free radical copolymerizations of monomer 3 with N-isopropylacrylamide 5 (NIPAAM) of different portions are carried out. The properties of polymers are characterized by use of gel permeation chromatography (GPC), dynamic light scattering (DLS) and turbidity measurements. The Lower Critical Solution Temperatures (LCSTs) of the copolymers with different portions of NIPAAM and influence of guest molecules addition by adamantly carboxylate and adamantly methyl methacrylate are evaluated.