期刊
JOURNAL OF PINEAL RESEARCH
卷 54, 期 3, 页码 264-270出版社
WILEY
DOI: 10.1111/j.1600-079X.2012.01030.x
关键词
melatonin; angiogenesis; HIF-1; tumor progression
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2009-0064997]
- Ministry of Education, Science and Technology (MEST) through the Creative Research Initiative Program [R16-2004-001-01001-0]
- National Research Foundation of Korea [R16-2004-001-01001-0, 2009-0064997] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The sustained expansion of a tumor mass requires new blood vessel formation to provide rapidly proliferating tumor cells with an adequate supply of oxygen and nutrients. Hypoxia-inducible factor-1 (HIF-1) plays an essential role in tumor angiogenesis and growth by regulating the transcription of genes in response to hypoxic stress. This study was designed to investigate the effects of melatonin on tumor growth and angiogenesis, as well as the mechanism underlying the antitumor activities of melatonin. In this study, we show that the administration of melatonin inhibits tumor growth and blocks tumor angiogenesis in mice. Moreover, melatonin diminished the expression of the HIF-1 protein within the tumor mass during tumorigenesis. Our findings suggest that melatonin is a promising anti-angiogenic therapeutic agent targeting HIF-1 in cancer. Considering that HIF-1 is overexpressed in a majority of human cancers, melatonin could offer a potent therapeutic agent for cancer.
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