期刊
JOURNAL OF PHYSIOLOGY-PARIS
卷 106, 期 1-2, 页码 47-56出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jphysparis.2011.06.001
关键词
Hair cells; Nicotinic receptors; alpha 9 and alpha 10 Nicotinic receptors; Synaptic plasticity; Prestin; Cochlea; SK channels
资金
- Howard Hughes Medical Institute
- Tinnitus Research Initiative
- NIH [R01 DC001508]
- University of Buenos Aires
- Consejo Nacional de Investigaciones Cientificas y Tecnicas
- Agencia Nacional de Promocion Cientifica y Tecnologica, Argentina
Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of alpha 9 and alpha 10 subunits, which is highly Ca2+ permeable and is coupled to a Ca2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse. (C) 2011 Elsevier Ltd. All rights reserved.
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