期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 597, 期 4, 页码 1033-1043出版社
WILEY
DOI: 10.1113/JP275852
关键词
hypoxia; mitochondria; redox signaling; pulmonary hypertension; pulmonary circulation
资金
- NIH [HL35440, HL122062, HL109478]
- Parker B. Francis Fellowship
When lung cells experience hypoxia, the functional response, termed hypoxic pulmonary vasoconstriction, activates a multitude of pathways with the goal of optimizing gas exchange. While previously controversial, overwhelming evidence now suggests that increased reactive oxygen species - produced at complex III of the mitochondrial electron transport chain and released into the intermembrane space - is the cellular oxygen signal responsible for triggering hypoxic pulmonary vasoconstriction. The increased reactive oxygen species (ROS) activate many downstream targets that ultimately lead to increased intracellular ionized calcium concentration and contraction of pulmonary arterial smooth muscle cells. While the specific targets of ROS signals are not completely understood, it is clear that this signalling pathway is critical for development and for normal lung function in newborns and adults.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据