期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 596, 期 21, 页码 5119-5133出版社
WILEY
DOI: 10.1113/JP276210
关键词
strength training; leucine; muscle mass; mTORC1; inflammation; TLR4
资金
- NHLBI NIH HHS [T32 HL130357] Funding Source: Medline
- ACSM Foundation Doctoral Student Grant Funding Source: Medline
We aimed to determine whether obesity alters muscle anabolic and inflammatory signalling phosphorylation and also muscle protein synthesis within the myofibrillar (MYO) and sarcoplasmic (SARC) protein fractions after resistance exercise. Nine normal weight (NW) (21 +/- 1 years, body mass index 22 +/- 1 kg m(-2)) and nine obese (OB) (22 +/- 1 years, body mass index 36 +/- 2 kg m(-2)) adults received l-[ring-C-13(6)]phenylalanine infusions with blood and muscle sampling at basal and fed-state of the exercise (EX) and non-exercise (CON) legs. Participants performed unilateral leg extensions and consumed pork (36 g of protein) immediately after exercise. Basal muscle Toll-like receptor 4 (TLR4) protein was similar between OB and NW groups (P > 0.05) but increased at 300 min after pork ingestion only in the OB group (P = 0.03). Resistance exercise reduced TLR4 protein in the OB group at 300 min (EX vs. CON leg in OB: P = 0.04). Pork ingestion increased p70S6K phosphorylation at 300 min in CON and EX of the OB and NW groups (P > 0.05), although the response was lower in the EX leg of OB vs. NW at 300 min (P = 0.05). Basal MYO was similar between the NW and OB groups (P > 0.05) and was stimulated by pork ingestion in the EX and CON legs in both groups (Delta from basal NW: CON 0.04 +/- 0.01% h(-1); EX 0.10 +/- 0.02% h(-1); OB: CON 0.06 +/- 0.01% h(-1); EX 0.06 +/- 0.01% h(-1); P < 0.05). MYO was more strongly stimulated in the EX vs. CON legs in NW (P = 0.02) but not OB (P = 0.26). SARC was feeding sensitive but not further potentiated by resistance exercise in both groups. Our results suggest that obesity may attenuate the effectiveness of resistance exercise to augment fed-state MYO.
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