期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 590, 期 3, 页码 441-446出版社
WILEY-BLACKWELL
DOI: 10.1113/jphysiol.2011.222133
关键词
-
资金
- National Institute for Health, National Institute for Diabetes and digestive and Kidney diseases, National Center for complimentry and alternative medicine
- Dairy Research Initiative
The gut epithelium is a barrier between the outside and inside world. The major function of the epithelium is to absorb nutrients, ions and water, yet it must balance these functions with that of protecting the inside world from potentially harmful toxins, irritants, bacteria and other pathogens that also exist in the gut lumen. The health of an individual depends upon the efficient digestion and absorption of all required nutrients from the diet. This requires sensing of meal components by gut enteroendocrine cells, activation of neural and humoral pathways to regulate gastrointestinal motor, secretory and absorptive functions, and also to regulate food intake and plasma levels of glucose. In this way, there is a balance between the delivery of food and the digestive and absorptive capacity of the intestine. Maintenance of the mucosal barrier likewise requires sensory detection of pathogens, toxins and irritants; breakdown of the epithelial barrier is associated with gut inflammation and may ultimately lead to inflammatory bowel disease. However, disruption of the barrier alone is not sufficient to cause frank inflammatory bowel disease. Several recent studies have provided compelling new evidence to suggest that changes in epithelial barrier function and inflammation are associated with and may even lead to altered regulation of body weight and glucose homeostasis. This article provides a brief review of some recent evidence to support the hypothesis that changes in the gut microbiota and alteration of gut epithelial function will perturb the homeostatic humoral and neural pathways controlling food intake and body weight.
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