期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 590, 期 2, 页码 301-308出版社
WILEY
DOI: 10.1113/jphysiol.2011.218362
关键词
-
资金
- National Institutes of Health [DC000241]
- Howard Hughes Medical Institute
Direct gating of mechanoelectrical transduction channels by mechanical force is a basic feature of hair cells that assures fast transduction and underpins the mechanical amplification of acoustic inputs, but the associated non-linearity -the gating compliance -inevitably distorts signals. Because reducing distortion would make the ear a better detector, we soughtmechanisms with that effect. Mimicking in vivo stimulation, we used stiff probes to displace individual hair bundles at physiological amplitudes and measured the coherence and phase of the relative stereociliary motions with a dual-beam differential interferometer. Although stereocilia moved coherently and in phase at the stimulus frequencies, large phase lags at the frequencies of the internally generated distortion products indicated dissipative relative motions. Tip links engaged these relativemodes and decreased the coherence in both stimulated and free hair bundles. These results show that a hair bundle breaks into a highly dissipative serial arrangement of stereocilia at distortion frequencies, precluding their amplification.
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