期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 589, 期 19, 页码 4745-4757出版社
WILEY
DOI: 10.1113/jphysiol.2011.215434
关键词
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资金
- Lundbeck Foundation
- Danish National Research Council (Medical Sciences: FSS)
- Danish Rheumatology Association
- Faculty of Health Sciences
- University of Copenhagen
- Danish Ministry of Culture
Very little attention has been given to the combined effects of healthy ageing and short-term disuse on the contractile function of human single muscle fibres. Therefore, the present study investigated the effects of 2 weeks of lower limb cast immobilisation (i.e. disuse) on selected contractile properties of single muscle fibres (n = 378) from vastus lateralis of nine young (24 +/- 1 years) and eight old (67 +/- 2 years) healthy men with comparable levels of physical activity. Prior to immobilisation, MHC IIa fibres produced higher maximum Ca2+-activated force (approx. 32%) and specific force (approx. 33%) and had lower Ca2+ sensitivity than MHCI fibres (P < 0.05), with no differences between young and old. After immobilisation, the decline in single fibre force (MHC I: young 21% and old 22%; MHC IIa: young 22% and old 30%; P < 0.05) as well as specific force (MHC I: young 14% and old 13%; MHC IIa: young 18% and old 25%; P < 0.05) was more pronounced in MHC IIa fibres compared to MHC I fibres (P < 0.05), with no differences between young and old. Notably, there was a selective decrease in Ca2+ sensitivity in MHC IIa fibres of young (P < 0.05) and in MHC I fibres of old individuals (P < 0.05), respectively. In conclusion, 2 weeks of lower limb immobilisation caused greater impairments in single muscle fibre force and specific force in MHC IIa than MHCI fibres independently of age. In contrast, immobilisation-induced changes in Ca2+ sensitivity that were dependent on age and MHC isoform.
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