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G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects
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The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1-NBD2 heterodimer
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Thermodynamics of CFTR channel gating:: A spreading conformational change initiates an irreversible gating cycle
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Structure of a bacterial multidrug ABC transporter
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The ABC protein turned chloride channel whose failure causes cystic fibrosis
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Differential sensitivity of the cystic fibrosis (CF)-associated mutants G551D and G1349D to potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel
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High affinity ATP/ADP analogues as new tools for studying CFTR gating
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Crystallographic and single-particle analyses of native and nucleotide-bound forms of the cystic fibrosis transmembrane conductance regulator (CFTR) protein
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Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells
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CFTR gating -: I:: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (ΔR-CFTR)
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CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains
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Impact of the ΔF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure
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Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain
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Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator
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Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulator
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Peptides induce ATP hydrolysis at both subunits of the transporter associated with antigen processing
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Distinct Mg2+-dependent steps rate limit opening and closing of a single CFTR Cl- channel
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