期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 586, 期 15, 页码 3701-3717出版社
WILEY
DOI: 10.1113/jphysiol.2008.153916
关键词
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资金
- Biotechnology and Biological Sciences Research Council [BB/C516779/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/C516779/1, BB/X510697/1] Funding Source: Medline
- NCRR NIH HHS [RR00954, P41 RR000954] Funding Source: Medline
- NIDDK NIH HHS [R01 DK059531, DK20579, R01 DK049393-11, DK49393, DK56341, P30 DK020579, DK74345, R01 DK049393, P30 DK056341, R21 DK074345, R56 DK049393, R01 DK049393-12, P30 DK056341-08, P60 DK020579, P30 DK056341-07, DK59531] Funding Source: Medline
Resistance (RE) and endurance (EE) exercise stimulate mixed skeletal muscle protein synthesis. The phenotypes induced by RE (myofibrillar protein accretion) and EE (mitochondrial expansion) training must result from differential stimulation of myofibrillar and mitochondrial protein synthesis. We measured the synthetic rates of myofibrillar and mitochondrial proteins and the activation of signalling proteins (Akt-mTOR-p70S6K) at rest and after an acute bout of RE or EE in the untrained state and after 10 weeks of RE or EE training in young healthy men. While untrained, RE stimulated both myofibrillar and mitochondrial protein synthesis, 67% and 69% (P < 0.02), respectively. After training, only myofibrillar protein synthesis increased with RE (36%, P = 0.05). EE stimulated mitochondrial protein synthesis in both the untrained, 154%, and trained, 105% (both P < 0.05), but not myofibrillar protein synthesis. Acute RE and EE increased the phosphorylation of proteins in the Akt-mTOR-p70S6K pathway with comparatively minor differences between two exercise stimuli. Phosphorylation of Akt-mTOR-p70S6K proteins was increased after 10 weeks of RE training but not by EE training. Chronic RE or EE training modifies the protein synthetic response of functional protein fractions, with a shift toward exercise phenotype-specific responses, without an obvious explanatory change in the phosphorylation of regulatory signalling pathway proteins.
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