期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 586, 期 6, 页码 1503-1508出版社
BLACKWELL PUBLISHING
DOI: 10.1113/jphysiol.2008.150722
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Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of fragile X and related disorders.
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