期刊
JOURNAL OF PHYSIOLOGICAL SCIENCES
卷 62, 期 3, 页码 251-257出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12576-012-0204-0
关键词
Reactive oxygen species; Prostate cancer cells; Hyperthermia; Ascorbic acid; Anti-oxidants; Anti-cancer drugs
类别
资金
- Grants-in-Aid for Scientific Research [24590280, 22136009, 11F01418, 24659100, 21590936] Funding Source: KAKEN
Cellular reactive oxygen species (ROS) production is increased by both temperature and anticancer drugs. Antioxidants are known to suppress ROS production while cancer patients may take them as dietary supplement during chemotherapy and hyperthermic therapy. We examined changes in ROS production in prostate cancer cells in the presence of various anticancer drugs and antioxidants at different temperatures. ROS production was increased with temperature in cancer cells, but not in normal cells; this increase was potently inhibited by ascorbic acid. ROS production was also increased in the presence of some anticancer drugs, such as vinblastine, but not by others. Dietary antioxidant supplements, such as beta-carotene, showed variable effects. Ascorbic acid potently inhibited ROS production, even in the presence of anticancer drugs, while beta-carotene showed no inhibition. Accordingly, our results suggest that cancer patients should carefully choose antioxidants during their cancer chemotherapy and/or hyperthermic therapy.
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