期刊
JOURNAL OF PHYSIOLOGICAL SCIENCES
卷 59, 期 5, 页码 391-396出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12576-009-0047-5
关键词
Cardiac hypertrophy; Pregnancy; Passive tension
类别
资金
- CONACyT-Mexico [42065, 143228]
- FRABA-UdeC
We evaluated changes in passive mechanical properties in cardiac tissues during rat pregnancy. Left and right ventricular free walls were dissected from hearts of nonpregnant, late-pregnant, and postpartum rats. Mechanical experiments in ventricular strips were done by stretch-release cycles using a step motor. The results show that during pregnancy, there is cardiac hypertrophy associated with (1) an increase in myocyte size, particularly of augmented myocyte length, (2) a decrease in passive tension developed by the myocardial walls, and (3) a decrease in both elastic modulus and hysteresis. All changes observed during rat pregnancy were reversed during postpartum. In conclusion, a heart with less ventricular rigidity could contribute to facilitating the ventricular filling in conditions of a greater circulating volume characteristic of pregnancy.
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