期刊
JOURNAL OF PHYSICS-CONDENSED MATTER
卷 20, 期 35, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0953-8984/20/35/354008
关键词
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资金
- German Research Foundation [1517/26-1-3]
- Israel Science Foundation [1116/05]
We investigate the applicability of the Jarzynski equality for reconstructing the energy landscape from force measurements obtained in single molecular unbinding and friction experiments. We demonstrate that single- well molecular potentials, such as the Lennard- Jones potential, could be accurately recovered using a reasonable number of force traces (similar to 100) obtained for velocities which are experimentally accessible, upsilon approximate to 5 - 100 nm s- 1. The situation becomes more complex in the presence of potential barriers in the energy profile. These include the double- well and periodic potentials that we consider here. The slow convergence of the reconstruction procedure results from a large energy dissipation which occurs during jumps across the potential barriers. We suggest a modification of the reconstruction procedure which allows the recovering of the correct shape of the potential wells even in the presence of potential barriers. However, a reconstruction of the potential shape in the vicinity of potential maxima requires additional information.
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