期刊
JOURNAL OF PHYSICS D-APPLIED PHYSICS
卷 43, 期 17, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0022-3727/43/17/175001
关键词
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资金
- Engineering and Physical Science Research Council
- National Research Foundation of Korea [2009-0064787, 2009-0069888]
- National Research Foundation of Korea [2009-0069888, 2009-0064787] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We present proof-of-principle experiments and simulations that demonstrate a new biological assay technology in which microscopic tags carrying multi-bit magnetic codes are used to label probe biomolecules. It is demonstrated that these 'micro-barcode tags' can be encoded, transported using micro-fluidics and are compatible with surface chemistry. We also present simulations and experimental results which suggest the feasibility of decoding the micro-barcode tags using magnetoresistive sensors. Together, these results demonstrate substantial progress towards meeting the critical requirements of a magnetically encoded, high-throughput and portable biological assay platform. We also show that an extension of our technology could potentially be used to label libraries consisting of similar to 10(4) distinct probe molecules, and could therefore have a strong impact on mainstream medical diagnostics.
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