期刊
PHYSICAL REVIEW LETTERS
卷 115, 期 24, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.115.248103
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资金
- Spanish Ministry of Economy and Competitiveness [BFU2012-38146]
- Generalitat de Catalunya [2014-SGR-927]
- European Research Council [StG-242993, CoG-616480]
- Obra Social la Caixa
- ICREA Funding Source: Custom
A general trait of cell monolayers is their ability to exert contractile stresses on their surroundings. The scaling laws that link such contractile stresses with the size and geometry of constituent cells remain largely unknown. In this Letter, we show that the active tension of an epithelial monolayer scales linearly with the size of the constituent cells, a surprisingly simple relationship. The slope of this relationship defines an active tensile modulus, which depends on the concentration of myosin and spans more than 2 orders of magnitude across cell types and molecular perturbations.
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