期刊
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
卷 69, 期 5-6, 页码 1560-1563出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpcs.2007.10.138
关键词
organic compounds; diffusion
资金
- NIBIB NIH HHS [R01 EB000260, R01 EB000260-03, R01 EB000260-04] Funding Source: Medline
- NIGMS NIH HHS [R01 GM060004-03, R01 GM060004-02, R01 GM060004, R01 GM060004-01A1] Funding Source: Medline
The skin's outer layer, stratum corneum, which is a thin tissue containing multilamellar lipid bilayers, is the main barrier to drug delivery through the skin. To increase skin permeability, our previous work has shown large enhancement of transdermal permeation using a pore-forming peptide, magainin, which was formulated with N-lauroyl sarcosine (NLS) in 50% ethanol-in-PBS. Mechanistic analysis suggested that magainin and NLS can increase skin permeability by disrupting stratum corneum lipid structure. In this study, our goal was to improve conditions that increase skin permeability by magainin by further optimizing the pretreatment time and concentration of magainin exposure. We found that skin permeability increased with increasing pretreatment time. Skin permeability also increased with increasing magainin concentration up to 1 mM, but was reduced at a magainin concentration of 2 mM. Enhancement of skin permeability to fluorescein (332 Da) up to 35-fold was observed. In contrast, this formulation did not enhance skin permeability to larger molecules, such as calcein (623 Da) and clextran (3000 Da). (c) 2007 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据