期刊
JOURNAL OF PHYSICAL CHEMISTRY C
卷 122, 期 36, 页码 21031-21038出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcc.8b04496
关键词
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资金
- Swedish Research Council [2016-05366, 20144423]
- Swedish Research Links [2017-05447]
- Research Environment Grant [2016-06264]
- Knut and Alice Wallenberg Foundation [KAW 2017.0055]
- Swedish Research Council [2017-05447] Funding Source: Swedish Research Council
There has been a perpetual interest in identifying suitable nano-carriers for drug delivery. In this regard, graphene-based two-dimensional materials have been proposed and demonstrated as drug carriers. In this paper, we have investigated the adsorption characteristics of a widely used anticancer drug, doxorubicin (DOX), on graphene (G) and graphene oxide (GO) by density functional theory calculations and fluorescence and X-ray photoelectron spectroscopies. From the calculated structural and electronic properties, we have concluded that G is a better binder of DOX compared to GO, which is also supported by our fluorescence measurements. The binding of DOX to G is mainly based on strong pi-pi stacking interactions. Consistent with this result, we also found that the sp(2) regions of GO interact with DOX stronger than the sp(3) regions attached with the functional groups; the binding is characterized by pi-pi and hydrogen-bonding interactions, respectively.
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