期刊
JOURNAL OF PHYSICAL CHEMISTRY C
卷 117, 期 20, 页码 10375-10382出版社
AMER CHEMICAL SOC
DOI: 10.1021/jp312163m
关键词
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资金
- National Natural Science Foundation of China [51075384, 51205385]
- Chinese Academy of Sciences
Casein phosphopeptides (CPPs) with abundant phosphoserine clusters can mediate hydroxyapatite (HA) nucleation and growth. In this work, a new type of CPPs-biofuctionalized graphene composite was synthesized by amidation reaction between CPPs and carboxyalated graphene (CGO). When immersed in stimulated body fluid (1.5 x SBF) at 37 degrees C for different periods, the CPPs layer on the composite facilitated efficient interaction between the CGO surface and mineral ions, which promoted HA nanoparticle formation and shortened mineralization time in comparison with pristine CGO. The synthesis of the composite mimicked the natural biomineralization of bone, demonstrating that CPPs can effectively improve the bioactivity of graphene and be useful for HA formation. The presented biocomposite may have potential biomedical applications in different areas.
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