期刊
JOURNAL OF PHYSICAL CHEMISTRY C
卷 117, 期 10, 页码 5286-5292出版社
AMER CHEMICAL SOC
DOI: 10.1021/jp401598a
关键词
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资金
- NSF [CHE-105801]
- CCNE [5U4CA151880-02]
- DARPA [N66001-11-1-4179]
- NSF-MRSEC
- NSF-NSC
- Keck Foundation
- Materials Processing and Microfabrication Facility
- MRSEC program of the NSF [DMR-1121262]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1058501] Funding Source: National Science Foundation
In this paper, we report critical design rules for improving the sensitivity of plasmonic biosensors. We use a scalable, parallel method to fabricate Au plasmonic crystal substrates patterned with an array of pits for real-time sensing. Capture ligands printed selectively in these pits resulted in a strong response to the binding of macromolecules. Angle-resolved sensorgrams showed quantitative differences between wavelength shifts produced by protein analyte bound within regions supporting localized and long-range electromagnetic fields. Contributions from the localized fields dominated the sensing response, especially at high angles. The angle-dependent far-field and near-field optical properties of selectively functionalized plasmonic crystals suggest that optimal performance is achieved at excitation parameters that produce an intense resonance with narrow spectral bandwidth and highly localized electromagnetic fields.
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