期刊
JOURNAL OF PHYSICAL CHEMISTRY C
卷 116, 期 3, 页码 2285-2291出版社
AMER CHEMICAL SOC
DOI: 10.1021/jp2086413
关键词
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资金
- Fundacao para a Ciencia e Tecnologia (FCT), Portugal [SFRH/BD/38313/2007, PTDC/CTM/73243/2006]
- CNRS
- Region Aquitaine France
- FEDER
- COST Action [D38]
- European FAME network of excellence
- Portuguese National NMR Network (RNRMN)
- Fundacao para a Ciencia e a Tecnologia (FCT)
- ARC [AUWB-2010-10/15 UMONS-5]
- FNRS
- ENCITE
- European Regional Development Fund
- Walloon Region
- Fundação para a Ciência e a Tecnologia [PTDC/CTM/73243/2006, SFRH/BD/38313/2007] Funding Source: FCT
Iron oxide nanoparticles with a constant superparamagnetic core coated with a silica shell with a thickness ranging from 0.6 to 71 nm were prepared by a fast and facile soft chemistry approach. The increase of the coating thickness of the gamma-Fe2O3@SiO2 nanoparticles causes a significant decrease of the r(1) and r(2) relaxivities of their aqueous suspensions. The sizes of the nanoparticles obtained by relaxometry are significantly lower than those measured by electron microscopy. Their magnetizations measured by relaxometry also decrease relative to the values obtained by magnetometry, which correspond to the core. However, this magnetic dilution is smaller than expected if the entire silica shell was water impermeable. Both results indicate that a significant part of the silica coating is permeable to water. The adequate silica shell thickness may, thus, be tuned to allow for both a sufficiently high response as contrast agent and an adequate grafting of targeted biomolecules.
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