期刊
JOURNAL OF PHYSICAL CHEMISTRY C
卷 114, 期 1, 页码 50-56出版社
AMER CHEMICAL SOC
DOI: 10.1021/jp9078986
关键词
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资金
- Shanghai Pujiang Program [09PJ1400600]
- National Natural Science Foundation of China [20974019, 30901730]
- National Basic Research Program of China (973 Program) [2007CB936000]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- Young Teacher Foundation of Donghua University [200802]
We report the X-ray attenuation property of den drimer-entrapped gold nanoparticles (Au DENPs) that could be used as a computed tomography (CT) contrast agent. Amine-terminated generation 5 (G5.NH2) poly(amidoamine) dendrimers were used as templates to complex AuCl4- ions for subsequent reductive formation of An DENPs using sodium borohydride as a reducing agent. By varying the molar ratio between gold salt to G5.NH2, An DENPs with a size range of 2-4 nm can be prepared. The formed An DENPs are not only stable in water, PBS buffer, and cell Culture media but also at different temperatures (from 4 to 50 degrees C) and different pH conditions (pH 5-8). X-ray absorption coefficient measurements show that the attenuation of An DENPs is much higher than that of the iodine-based contrast agent at the same molar concentration of the active element (An versus iodine). Furthermore, CT scanning showed significant enhancement at the point of mice injected subcutaneously with Au DENPs, and intravenous injection of acetylated An DENPs enabled the X-ray CT imaging of mice, rendering them a promising contrast agent in CT imaging applications.
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