期刊
JOURNAL OF PHYSICAL CHEMISTRY B
卷 117, 期 48, 页码 14894-14906出版社
AMER CHEMICAL SOC
DOI: 10.1021/jp408440z
关键词
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资金
- National Institute of Biomedical Imaging and Bioengineering of the National Institute of Health [EB-002804, EB-003151, EB-001960, EB-002026]
- Natural Sciences and Engineering Research Council of Canada
- Deutsche Forschungsgemeinschaft [CO 802/1-1]
Dynamic nuclear polarization of O-17 was studied using four different polarizing agents: the biradical TOTAPOL and the monoradicals trityl and SA-BDPA, as well as a mixture of the latter two. Field profiles, DNP mechanisms, and enhancements were measured to better understand and optimize directly polarizing this low-gamma quadrupolar nucleus using both mono- and biradical polarizing agents. Enhancements were recorded at <88 K and were >100 using the trityl (OX063) radical and <10 with the other polarizing agents. The >10 000-fold savings in acquisition time enabled a series of biologically relevant small molecules to be studied with small sample sizes and the measurement of various quadrupolar parameters. The results are discussed with comparison to room temperature studies and GIPAW quantum chemical calculations. These experimental results illustrate the strength of high field DNP and the importance of radical selection for studying low-gamma nuclei.
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