期刊
JOURNAL OF PHYSICAL CHEMISTRY B
卷 117, 期 5, 页码 1494-1500出版社
AMER CHEMICAL SOC
DOI: 10.1021/jp3106716
关键词
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资金
- U.S. Department of Energy, Office of Science
- Office of Basic Energy Sciences
- National Science Foundation Engineering Research Center for Structured Organic Particulate Systems [EEC-0540855]
- [NIH-R01GM103401]
The crystallization kinetics of naproxen (NAP) in NAP/polyethylene glycol (NAP/PEG) solid dispersions prepared at different crystallization temperatures was studied by in situ small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS). It was found that the crystallization rate of NAP was faster at 25 degrees C in comparison to 40 degrees C. This resulted in different sizes of NAP domains, and consequently impacted the dissolution behavior. The sizes of NAP domains prepared at 40 degrees C were larger than those at 25 degrees C, as determined with surface area analysis, utilizing second-order nonlinear optical imaging of chiral crystals (SONICC). Consistent with this observation, the corresponding dissolution rate of the NAP/PEG dispersion prepared at 40 degrees C was indeed slower than that prepared at 25 degrees C. The microstructure of the NAP/PEG solid dispersions and the dissolution behavior also showed a dependence on the chemical composition of the solid dispersions.
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