期刊
JOURNAL OF PHYSICAL CHEMISTRY B
卷 113, 期 9, 页码 2748-2763出版社
AMER CHEMICAL SOC
DOI: 10.1021/jp807056c
关键词
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资金
- NIH [5PN2EYO 16570-05]
- NSF Teragrid
We introduce a new force field (43A1-S3) for simulation of membranes by the Gromacs simulation package. Construction of the force fields is by standard methods of electronic structure computations for bond parameters and charge distribution and specific volumes and heats of vaporization for small-molecule components of the larger lipid molecules for van der Waals parameters. Some parameters from the earlier 43A1 force field are found to be correct in the context of these calculations, while others are modified. The validity of the force fields is demonstrated by correct replication of X-ray form factors and NMR order parameters over a wide range of membrane compositions in semi-isotropic NTP 1 atm simulations. 43-A1-S3 compares favorably with other force fields used in conjunction with the Gromacs simulation package with respect to the breadth of phenomena that it accurately reproduces.
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