期刊
JOURNAL OF PHYSICAL CHEMISTRY B
卷 113, 期 23, 页码 8137-8141出版社
AMER CHEMICAL SOC
DOI: 10.1021/jp900379w
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资金
- Research and Development Office for Health and Personal Social Services in Northern Ireland [EAT/2538/03]
- Perkin-Elmer Inc.
- The Faraday Institute
Lung cancer is the most common cause of cancer death. The conventional method of confirming the diagnosis is bronchoscopy, inspecting the airways of the patient with a fiber optic endoscope. A number of studies have shown that Raman spectroscopy can diagnose lung cancer in vitro. In this study, Raman spectra were obtained from ex vivo normal and malignant lung tissue using a minifiber optic Raman probe suitable for insertion into the working channel of a bronchoscope. Shifted subtracted Raman spectroscopy was used to reduce the fluorescence from the lung tissue. Using principal component analysis with a leave-one-out analysis, the tissues were classified accurately. This novel technique has the potential to obtain Raman spectra from tumors from patients with lung cancer in vivo.
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