The strong MRI relaxivity of paramagnetic nanoparticles

We developed a method to synthesize paramagnetic nanoparticles of Gd@C-82(OH)(22 +/- 2). Such nanoparticles are with ordered microstructures and have strong MRI proton relaxation in vitro/vivo. Compared with commercial Gd-DTPA, a 12 x MRI relaxivity of Gd@C-82(OH)(22 +/- 2) nanoparticles with ordered microstructures was achieved in vitro. The small Gd@C-82(OH)(22 +/- 2) nanoparticles, similar to 65nm, could easily escape the RES uptake in vivo; this opens the door for their clinical applications.