期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
卷 128, 期 -, 页码 20-26出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2013.08.005
关键词
Mesalamine; CT-DNA; Groove binding; Molecular docking
资金
- Razi University Research Center
The interaction of CT-DNA with the drug mesalamine (5-ASA) at physiological pH has been investigated by absorption, emission, circular dichroism (CD), cyclic voltammetry (CV), viscosity studies and molecular modeling. Thermodynamic parameters (Delta H > 0 and Delta S < 0) indicated that hydrogen bond and van der Waals play main roles in the binding of 5-ASA to CT-DNA. Ethidium bromide (EB) displacement studies revealed that 5-ASA did not have any effect on ethidium bromide (EB) bound DNA which is indicative of groove binding. The results obtained from experimental and molecular modeling showed that 5-ASA is a minor groove binder of DNA and preferentially binds to GC rich regions. (C) 2013 Elsevier B.V. All rights reserved.
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