期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
卷 110, 期 -, 页码 50-57出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2012.03.004
关键词
PDT; Methyl pyropheophorbide-a; Unsaturated fatty acid; Photosensitizer; Phototoxicity; Synthesis
Chlorin-based photosensitizers in photodynamic therapy are the promising anticancer agents, but some of their properties such as specific-targeting to tumor need to be improved. The aim of this study was to synthesize chlorin-based unsaturated fatty acid conjugates to obtain an optimal photosensitizers. Thus four chlorin-based fatty acid conjugates were successfully synthesized through an esterification reaction using carbodiimide coupling reagents in enough yields. Then, structures of these conjugates were confirmed by H-1 NMR, MALDI-MS, and UV-vis spectroscopy. Furthermore, their in vitro phototoxicity and cellular uptake were evaluated on TC-1 lung cancer cell line and HeLa cell line. (C) 2012 Elsevier B.V. All rights reserved.
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