期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
卷 102, 期 3, 页码 200-208出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2010.12.004
关键词
Chalcones; Spin trapping; Singlet oxygen; Superoxide anion; DNA cleavage
资金
- UGC, New Delhi
This paper describes the synthesis and photodynamic properties of six different chalcone derivatives. Using N,N-dimethyl-4-nitrosoaniline (RNO) bleaching assay, the singlet oxygen generating efficiencies of these chalcones are determined relative to rose bengal (RB). Superoxide dismutase (SOD) inhibitable cytochrome c reduction assay and electron magnetic resonance (EMR) spin trapping techniques are used to determine the superoxide anion radical (O-2(center dot-)) yield upon photoirradiation. Photoinduced DNA scission studies show that O-2(center dot-) is involved in the DNA strand break. In addition, antimicrobial activity of these chalcones is also investigated. Structure activity relationship accounts for the difference in the photogeneration of reactive oxygen species (ROS) by these sensitizers. Presence of electron releasing -OCH3 groups enhances the photogeneration of ROS. Cyclic voltammetry studies indicate a correlation between enzymatic O-2(center dot-) generation efficiency and redox potential of chalcones. Both O-2(center dot-) (Type I) and O-1(2) (Type II) paths are involved in the photosensitization of chalcones. The LUMO energies obtained by molecular modeling correlate with the one-electron reduction potentials. (C) 2010 Elsevier B.V. All rights reserved.
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