期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
卷 367, 期 -, 页码 45-55出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2018.08.004
关键词
Zinc phthalocyanine; Photodynamic therapy; Nuclear imaging; Titanium nanoparticle
资金
- Scientific and Technological Research Council of Turkey, TUBITAK [114Z430]
In this study, Subphthalocyanine (SubPc) and SubPc integrated TiO2 nanoparticles (SubPc- TiO2) were examined as theranostic agents. In vitro photodynamic therapy (PDT) efficiency of SubPc/SubPc-TiO2 and nuclear imaging potential of I-131 labeled SubPc/TiO2-SubPc were determined on hepatocellular carcinoma (HepG2), colorectal adenocarcinoma (HT29) and human healthy lung (WI38) cell lines. As a result, I-131-SubPc and I-131-SubPc-TiO2 have been identified as a nuclear imaging agent for liver cancer. Additionally, I-131-SubPc-TiO2 has been found to be promising for imaging colon tumors. According to the in vitro photodynamic therapy studies, SubPc and SubPc-TiO2 were determined suitable PDT agents for liver and colon tumors. These results suggest that SubPc: TiO2 might be a theranostic agent with both PDT and nuclear imaging potential.
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