期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
卷 282, 期 -, 页码 41-46出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2014.03.009
关键词
BODIPY; Fluorescence quenching; Cu2+ Sensor; Biothiols sensor; Cell images
资金
- Ministry of Science and Technology [2013CB834804, 2012DFH40090]
- Natural Science Foundation of China (NSFC) [21071123, 21273257, U1137606]
- Yunnan Key Project [2010CC007]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0979]
A new fluorescent boron dipyrromethene (Bodipy) derivative 1 containing a di(2-picolyl)amine group as a binding site for Cu2+ was synthesized and characterized. Compound 1 behaves as an on off fluorescent sensor for highly selective and sensitive detection of Cu2+ ions. The selective interaction between compound I and Cu2+ leads to formation of a 1 center dot Cu2+ complex, associated with quenching of the fluorescence of 1. An investigation into the detection of biothiols shows that the 1 center dot Cu2+ complex has better recognition for glutathione than cysteine and homocysteine in CH3OH-HEPES (1:1, v/v) buffer solution at pH 7.4 (HEPES = 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid). In addition, fluorescence images obtained via confocal microscopy reveal that compound 1 exhibits excellent selectivity and high sensitivity for Cu2+ under physiological conditions and in living cells. (C) 2014 Elsevier B.V. All rights reserved.
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