期刊
JOURNAL OF PHARMACY AND PHARMACOLOGY
卷 70, 期 12, 页码 1606-1618出版社
WILEY
DOI: 10.1111/jphp.13010
关键词
bioinformatics analysis; breast cancer; epigallocatechin 3-gallate; focal adhesion kinase signalling pathway
资金
- Science and Technology Development Plan Project of Jilin Province [20150204082SF]
Objectives This study aimed to investigate potential gene and signal pathway associated with tumour progression. Methods Key findings Related microarray data set of breast cancer was obtained from Gene Expression Omnibus database, and differential-expressed genes (DEGs) between two control samples and two treated samples were analysed using statistical software R. We collected 50 epigallocatechin-3-gallate(EGCG)-related genes and 119 breast cancer-related genes to create a knowledge base for following pathway analysis. A total of 502 mRNAs were identified as DEGs based on microarray analysis. Upregulated DEGs mainly enriched in nuclear nucleosome, cell adhesion, DNA packaging complex, Wnt-activated receptor activity, etc., while the downregulated DEGs significantly enriched in ncRNA processing, mitotic nuclear division, DNA helicase activity, etc. DEGs mostly enriched in gap junction, cell cycle, oxidative phosphorylation, focal adhesion, etc. EGCG suppressed FAK signalling pathway. Furthermore, EGCG could inhibit breast cancer cell proliferation and promote apoptosis by modulating CCND1. Conclusions Epigallocatechin 3-gallate might exert influence on breast cancer progression through inhibiting focal adhesion kinase (FAK) signalling pathway.
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