期刊
JOURNAL OF PHARMACY AND PHARMACOLOGY
卷 66, 期 1, 页码 133-144出版社
OXFORD UNIV PRESS
DOI: 10.1111/jphp.12156
关键词
curcumin; cytokines; FCA-induced arthritis; oxidative stress; prednisolone
资金
- CSIR under SMiLE [CSC 0111]
ObjectivesThe present study was aimed at investigating the effect of curcumin in combination with prednisolone for the effective treatment of arthritis with reduced side effects when glucocorticoids therapy is indicated. MethodsArthritis was induced in wistar rats by subplantar injection of Freund's complete adjuvant, and animals were observed for the symptoms of arthritis during the period of 21 days. Combined treatment of curcumin with various doses of prednisolone (1.25, 2.5 and 5mg/kg) was evaluated in order to ascertain the efficacy and toxicity induced by steroid. Key findingsArthritic animals showed significant increase in tumour necrosis factor- and IL-1 levels in paw tissue and IL-1 in serum. Combined therapy of curcumin with low doses of prednisolone showed pronounced beneficial effect on joint swelling, leucocyte count and biochemical parameters compared with prednisolone groups. Among the different doses used in the study, prednisolone at 1.25 mg/kg in combination with curcumin showed beneficial anti-arthritic activity and also reduced the steroid toxicity. This is evidenced by increase in body weight, low toxicity to immune organs, reduction in leucocyte count, increase in spleen anti-oxidant enzymes and potent inhibition of cytokines in combination group. ConclusionTherefore, combined treatment of curcumin with low doses of prednisolone may find therapeutic use in arthritis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据