期刊
JOURNAL OF PHARMACY AND PHARMACOLOGY
卷 64, 期 12, 页码 1703-1708出版社
WILEY
DOI: 10.1111/j.2042-7158.2012.01561.x
关键词
cardio vascular disease; diabetes mellitus; fetuin-A; insulin resistance; vascular calcification
Objectives Fetuin-A is a circulating glycoprotein, formed in the liver. It regulates bone remodelling and calcium metabolism. Fetuin-A has adipogenic properties, so fat accumulation in the liver may be associated with higher levels of fetuin-A. Fetuin-A is an inhibitor of the phosphorylation of the insulin receptor tyrosine kinase. Key findings High concentrations of fetuin-A in humans causes insulin resistance. Insulin sensitivity is also found to be increased in fetuin-A knockout mice. Fetuin-A has been shown to cause insulin resistivity in type-2 diabetes mellitus and worsens the pro-atherogenic milieu. Summary Fetuin-A should be considered as a hepatic bio-marker. Vascular diseases like atherosclerosis are major causes of disability in patients with diabetes mellitus.
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