期刊
JOURNAL OF PHARMACY AND PHARMACOLOGY
卷 64, 期 3, 页码 326-336出版社
WILEY
DOI: 10.1111/j.2042-7158.2011.01391.x
关键词
drug interaction; drug transporter; everted sac; P-glycoprotein
Objectives This review discusses the limitations and applications of the everted gut sac model in studying drug absorption, metabolism, and interaction. Key findings The mechanism of drug absorption, interaction and the effect of factors such as age, sex, species, chronic therapy, and disease state on drug absorption have been summarized. The experimental conditions and their effects on the outcomes of trials have been discussed also. Summary The everted sac model is an efficient tool for studying in-vitro drug absorption mechanisms, intestinal metabolism of drugs, role of transporter in drug absorption, and for investigating the role of intestinal enzymes during drug transport through the intestine.
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